KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
21.52
Human Site:
S375
Identified Species:
59.17
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
S375
Y
K
D
I
F
L
D
S
D
C
K
D
D
T
S
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
S405
Y
K
D
M
F
L
D
S
N
F
T
D
T
E
S
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
S367
Y
K
D
M
F
F
S
S
G
F
Q
D
A
G
H
Dog
Lupus familis
XP_548885
1422
158482
S471
Y
K
D
I
F
L
D
S
D
C
K
D
D
T
S
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
S379
Y
K
D
I
F
L
D
S
G
C
E
E
D
A
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
S461
Y
K
D
M
F
L
D
S
D
C
E
D
N
E
S
Chicken
Gallus gallus
XP_419725
1260
143069
R339
F
D
T
S
F
E
L
R
K
V
G
V
K
I
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
S391
Y
K
D
M
F
L
D
S
H
F
T
D
T
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
L345
N
L
A
T
L
L
V
L
A
G
K
E
F
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
60
40
100
N.A.
73.3
N.A.
N.A.
73.3
13.3
N.A.
60
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
73.3
53.3
100
N.A.
86.6
N.A.
N.A.
93.3
20
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
0
0
0
12
0
0
0
12
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
45
0
0
0
0
0
% C
% Asp:
0
12
78
0
0
0
67
0
34
0
0
67
34
0
0
% D
% Glu:
0
0
0
0
0
12
0
0
0
0
23
23
0
23
0
% E
% Phe:
12
0
0
0
89
12
0
0
0
34
0
0
12
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
23
12
12
0
0
12
0
% G
% His:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
12
% H
% Ile:
0
0
0
34
0
0
0
0
0
0
0
0
0
12
0
% I
% Lys:
0
78
0
0
0
0
0
0
12
0
34
0
12
0
12
% K
% Leu:
0
12
0
0
12
78
12
12
0
0
0
0
0
0
0
% L
% Met:
0
0
0
45
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
0
0
0
0
0
0
12
0
0
0
12
12
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
12
0
0
12
78
0
0
0
0
0
0
78
% S
% Thr:
0
0
12
12
0
0
0
0
0
0
23
0
23
34
0
% T
% Val:
0
0
0
0
0
0
12
0
0
12
0
12
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
78
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _